Precautions:

• Topical retinoids, retinols, strong acids, or benzoyl peroxide – stop use at least 3–5 days before infusion to prevent overstimulation

• Recent professional exfoliation, chemical peel, laser, or microneedling (skin must heal first, usually 1–2 weeks)

• Recent Botox or filler injections (wait at least 2 weeks before infusion)

• Recent waxing, threading, or depilatory creams (wait a few days)

• Excessive sun exposure/tanning within 48 hours before or after treatment

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Relative Contraindications (use caution, may require modifications):

• Compromised skin barrier (eczema, dermatitis, psoriasis flare-ups, rosacea in acute state)

• History of keloid or hypertrophic scarring

• Diabetes (uncontrolled) due to delayed wound healing (though infusion is non-invasive, it still stimulates activity)

• Post-inflammatory hyperpigmentation risk (Fitzpatrick IV–VI require more caution, especially with vitamin A)

Absolute Contraindications (treatment should NOT be performed):

• Scleroderma

• Open wounds, cuts, abrasions, sunburn, rashes or skin infections

• Active skin infections (bacterial, viral, fungal – including cold sores, impetigo, or warts in treatment area)

• Severe cases of Rosacea

• Diabetes or other Auto-immune system disorders

• Immunocompromised from chemotherapy, radiation therapy, or high dose steroids

• Known allergy to vitamin A derivatives, niacinamide, or any infusion ingredients